Evidence Heatmap
All interventions by tier, colored by evidence strength. Purple dots indicate high community interest.
Trending in Communityβ Most discussed on longevity forums
BPC-157C+Semaglutide (GLP-1 Agonist)ARapamycin (Sirolimus)B-Nicotinamide Mononucleotide (NMN)B-MetforminB+Creatine MonohydrateAAshwagandha (KSM-66)BNicotinamide Riboside (NR)B-Vitamin D3ATime-Restricted Eating (Intermittent Fasting)B+Cold Exposure (Cold Plunge/Shower)B-Omega-3 Fatty Acids (EPA/DHA)B+Sauna Use (Finnish-style)B+NAD+ IV InfusionC+Stem Cell TherapyC+BerberineB+Epithalon (Epitalon)C+FisetinC+
Tier 1Foundations(29)
Alcohol Reduction/EliminationBalance & Stability TrainingCircadian Rhythm ManagementHigh Fiber IntakeFlexibility & Mobility TrainingHigh-Intensity Interval Training (HIIT)Optimal HydrationMediterranean DietOral Hygiene & Dental HealthPlant-Based/Whole Food DietProtein Optimization (1.6-2.2g/kg)Sleep Hygiene ProtocolsSleep OptimizationSmoking CessationSocial Connection & CommunityResistance/Strength TrainingChronic Stress ReductionVO2 Max TrainingDaily Walking (10,000+ Steps)Zone 2 Cardiovascular TrainingAnti-Inflammatory DietCaloric RestrictionCognitive Training & LearningMeditation & MindfulnessSauna Use (Finnish-style)Time-Restricted Eating (Intermittent Fasting)Ketogenic DietNasal Breathing PracticeModerate Sun Exposure
Tier 2Optimization(59)
Creatine MonohydrateIodinePsyllium Husk FiberVitamin D3BerberineContinuous Glucose MonitoringL-TheanineMelatonin (Low-dose)Extra Virgin Olive Oil PolyphenolsOmega-3 Fatty Acids (EPA/DHA)Probiotics (Multi-strain)Vitamin CZincAcetyl-L-Carnitine (ALCAR)Alpha-Lipoic AcidAshwagandha (KSM-66)B-Vitamin ComplexBlue Light Blocking (Evening)Breathwork ProtocolsCollagen PeptidesCoenzyme Q10 (CoQ10/Ubiquinol)Curcumin (Turmeric Extract)DHEAGlycineGreen Tea Extract (EGCG)Continuous Heart Rate Variability (HRV) MonitoringMagnesium (Glycinate/Threonate)N-Acetyl Cysteine (NAC)Pine Bark Extract (Pycnogenol)Red/Near-Infrared Light TherapySeleniumVitamin K2 (MK-7)AstaxanthinBlack Seed Oil (Nigella Sativa)Cold Exposure (Cold Plunge/Shower)Lion's Mane MushroomGut Microbiome TestingPalmitoylethanolamide (PEA)PhosphatidylserineQuercetinResveratrolSpermidineSulforaphane (Broccoli Extract)TaurineTongkat Ali (Eurycoma Longifolia)Urolithin AApigeninBoronC15:0 (Pentadecanoic Acid / Fatty15)Cistanche TubulosaEcdysterone (Beta-Ecdysterone)ErgothioneineFisetinGrounding/EarthingMouth Taping (Nasal Breathing Training)Pyrroloquinoline Quinone (PQQ)Shilajit (Purified Fulvic Acid Complex)TurkesteroneFadogia Agrestis
Tier 3Advanced(45)
Low-Dose AspirinComprehensive Blood Panel MonitoringCoronary Artery Calcium ScoreDEXA Scan (Body Composition)Estrogen/HRT (Menopause)Semaglutide (GLP-1 Agonist)SGLT2 InhibitorsStatins (for CVD Prevention)Thyroid Hormone OptimizationTirzepatide (Dual GIP/GLP-1 Agonist)AcarboseAdvanced Lipid Panel (NMR/Ion Mobility)Biological Age Testing (Epigenetic Clocks)Galleri Multi-Cancer Early Detection TestGrowth Hormone (HGH)MetforminNiacin (Nicotinic Acid/NAD+ Precursor)Testosterone Replacement Therapy (TRT)Full-Body MRI ScreeningHyperbaric Oxygen Therapy (HBOT)Transcranial Direct Current Stimulation (tDCS)TruAge Epigenetic Clock TestingVagus Nerve Stimulation (VNS)GlycanAge (Glycan-Based Biological Age Test)Low-Dose LithiumNicotinamide Riboside (NR)Nicotinamide Mononucleotide (NMN)PT-141 (Bremelanotide)Rapamycin (Sirolimus)SS-31 (Elamipretide)Tadalafil (Low-Dose)Thymosin Alpha-1AI-Personalized NutritionBPC-157Dasatinib + Quercetin (Senolytic)Dasatinib (Standalone Senolytic)Epithalon (Epitalon)Ghrelin Mimetics (MK-677/Ipamorelin)Methylene Blue (Low-dose)NAD+ IV InfusionOzone TherapyRapamycin + Metformin CombinationTopical Rapamycin (Skin Aging)FOXO4-DRI (Senolytic Peptide)17-alpha-Estradiol
Tier 4Frontier(24)
CRISPR Gene EditingAI-Driven Drug Discovery for AgingBrain-Computer InterfacesExosome TherapyGene Therapy (Follistatin, Telomerase, etc.)Mitochondrial TransplantationNanotechnology MedicineNext-Gen Senolytics (Clinical Pipeline)Stem Cell TherapyTelomere Extension TherapiesUBX0101 (Senolytic for Osteoarthritis)Xenotransplantation (Pig Organs)Young Plasma Exchange/ParabiosisNavitoclax (ABT-263)3D Organ BioprintingPartial Cellular Reprogramming (Yamanaka Factors)Cellular Senescence VaccineChemical Epigenetic Reprogramming (Yamanaka-Free)GDF11 (Growth Differentiation Factor 11)Klotho Protein TherapymRNA Longevity TherapiesWhole-Body Organ ReplacementCryonics/CryopreservationDigital Consciousness/Mind Upload
Evidence:|Community Signal